PH VE İYON KUVVETİNİN İYON DEĞİŞTİRİCİLERİN YÜKLEME VE SALIM ÖZELLİKLERİ ÜZERİNE ETKİSİNİN İNCELENMESİ

Objective: Ion-exchangers are inert, water-insoluble polymers with ionizable functional groups on their surface. They can be used for purposes such as disintegrating or taste masking in orally dosage forms, they provide a pH-dependent controlled release.
 Material and Method: The loading release properties of different cation exchangers were investigated by Atenolol to Amberlite CG50, Dowex 50W-X2 Smopex 101 weak strong resin fiber, respectively. effect the ionic strength medium capacities these materials water pH 7.4 HEPES buffer using batch method was monitored pH, zeta potential, FTIR SEM analysis. Loading capacity calculated UV spectrophotometrically. atenolol dialysis bag 1.2 HCl, 6.8 PBS media. 
 Result Discussion: Due its low molecular weight high pKa successfully loaded over 93%. As could balanced higher achieved buffer. decrease potential values proved that complexes obtained also new bands occured micrographs. did not medium, contrarily 6.8, which ionize. amount counter ions affected release. highest rate Amberlite. All ion-exchangers provided fitting Higuchi Zero order kinetics shows diffusion. Boyd equation results showed diffusion mechanism particle controlled.